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kinetic hdac2 assay kit (BPS Bioscience)

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BPS Bioscience kinetic hdac2 assay kit
Kinetic Hdac2 Assay Kit, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 92/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/kinetic+hdac2+assay+kit/HDAC2+Kinetic+Assay+Kit/pm34959179-357-50-67
Average 92 stars, based on 6 article reviews

kinetic hdac2 assay kit - by Bioz Stars, 2026-10

92/100 stars

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Article Title: Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors.
Article Snippet: Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3-cyanopyridines as a novel cap moiety linked with aliphatic /aromatic linker bearing carboxylic acid 3a-g, hydroxamic acid 4a-g or 2-aminoanilide moieties 5a-g as zinc-binding group.. Most of the target hybrids revealed promising growth inhibition according to one dose NCI protocol against 60 cancer cell lines.. Meanwhile, hydroxamic acids 4b, 4d and 4e displayed strong and broad-spectrum activity against nine tumor subpanels tested (GI50 0.176–8.87 μM); 4d displayed strong antiproliferative activity with GI50 ≤ 3 μM against different cancer cell lines (GI50 range from 0.325 to 2.9 μM).

Article Title: The Multifunctional Protein PACS-1 is Required for HDAC2 and HDAC3 Dependent Chromatin Maturation and Genomic Stability
Article Snippet: The eluted proteins were either sent to MS Bioworks LLC, Ann Arbor, MI for proteome analysis or suspended in Laemelli buffer (161-0737, Biorad, USA) and analyzed by western blot. .. HDAC activity was measured with the fluorometric HDAC3 Activity Assay kit (EP1004, Sigma, St Louis, MO) and kinetic HDAC2 assay kit (53002, BPS biosciences, USA) according to the manufacturer’s instructions. ..

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(A) Chelating interaction formed between benzamide inhibitor (LLX) and the zinc ion (red) present in the human HDAC2 active site. Both carbonyl oxygen and ortho-NH2 groups form bi-dentate covalent interactions with the zinc ion. (B) Hydrogen bond interactions between ortho-NH2 group and His145/His146; carbonyl oxygen and Tyr308; π-π stacking interactions between the benzamide ring and Phe155/Phe210.

Journal: Combinatorial chemistry & high throughput screening

Article Title: Discovery of a Novel HDAC2 Inhibitor by a Scaffold-Merging Hybrid Query

doi:

Figure Lengend Snippet: (A) Chelating interaction formed between benzamide inhibitor (LLX) and the zinc ion (red) present in the human HDAC2 active site. Both carbonyl oxygen and ortho-NH2 groups form bi-dentate covalent interactions with the zinc ion. (B) Hydrogen bond interactions between ortho-NH2 group and His145/His146; carbonyl oxygen and Tyr308; π-π stacking interactions between the benzamide ring and Phe155/Phe210.

Article Snippet: The HDAC2 assay kit 24 was purchased from BPS Bioscience (San Diego, CA).

Techniques:

(Top) The hybrid query derived from multiple known HDAC2 inhibitor classes, which includes Hydroxamate phenylisoxazole, Triazole, Hydroxamate and Isoxazole; (Bottom) The single molecule query generated from LLX in 3MAX, comprised of carbonyl oxygen, ortho-N act as anions, H-bond acceptor and donor respectively.

Journal: Combinatorial chemistry & high throughput screening

Article Title: Discovery of a Novel HDAC2 Inhibitor by a Scaffold-Merging Hybrid Query

doi:

Figure Lengend Snippet: (Top) The hybrid query derived from multiple known HDAC2 inhibitor classes, which includes Hydroxamate phenylisoxazole, Triazole, Hydroxamate and Isoxazole; (Bottom) The single molecule query generated from LLX in 3MAX, comprised of carbonyl oxygen, ortho-N act as anions, H-bond acceptor and donor respectively.

Article Snippet: The HDAC2 assay kit 24 was purchased from BPS Bioscience (San Diego, CA).

Techniques: Derivative Assay, Generated

(Top) The inhibitory curves of ST088357 against human HDAC2 and its IC50 value; (Middle) The most similar compounds to ST088357 from known HDAC2 inhibitors measured by the highest Tanimoto coefficient (Tc) calculated by MACCS and FCFP_6 fingerprints; (Bottom) The inhibition rate (%) of ST088357 against human HDAC1, HDAC2, and HDAC6 at 100 μM.

Journal: Combinatorial chemistry & high throughput screening

Article Title: Discovery of a Novel HDAC2 Inhibitor by a Scaffold-Merging Hybrid Query

doi:

Figure Lengend Snippet: (Top) The inhibitory curves of ST088357 against human HDAC2 and its IC50 value; (Middle) The most similar compounds to ST088357 from known HDAC2 inhibitors measured by the highest Tanimoto coefficient (Tc) calculated by MACCS and FCFP_6 fingerprints; (Bottom) The inhibition rate (%) of ST088357 against human HDAC1, HDAC2, and HDAC6 at 100 μM.

Article Snippet: The HDAC2 assay kit 24 was purchased from BPS Bioscience (San Diego, CA).

Techniques: Inhibition

The complexes of ST088357 bound to human HDAC2. The residues close to the ligand with the cutoff distance of 8 Å were rendered by PyMOL software.

Journal: Combinatorial chemistry & high throughput screening

Article Title: Discovery of a Novel HDAC2 Inhibitor by a Scaffold-Merging Hybrid Query

doi:

Figure Lengend Snippet: The complexes of ST088357 bound to human HDAC2. The residues close to the ligand with the cutoff distance of 8 Å were rendered by PyMOL software.

Article Snippet: The HDAC2 assay kit 24 was purchased from BPS Bioscience (San Diego, CA).

Techniques: Software

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kinetic hdac2 assay kit (BPS Bioscience)

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